Neil Renwick, MD, PhD

Neil Renwick Neil Renwick obtained his MD from the University of Otago, New Zealand in 1993, PhD (Virology) from the University of Amsterdam, The Netherlands in 2001, and trained in Anatomic Pathology/Molecular Pathology at Columbia University Medical Center (CUMC) prior to board certification in 2005. Following residency, Neil designed pathogen detection and discovery assays in the Northeast Biodefense Center, CUMC, making full use of his clinical work as a medical officer in Australia, Papua New Guinea, and Thailand from 1994-6. These formative experiences provide a strong basis for assessing and articulating health needs, designing assays, and performing clinicopathologic correlations.

In 2007, Neil was accepted into the Clinical Scholars Program at The Rockefeller University, joining the Laboratory of RNA Molecular Biology as an Instructor in Clinical Investigation. Under the expert supervision of Prof. Thomas Tuschl, a pioneer in the field of small RNA biology, Neil designed state-of-the-art microRNA (miRNA) detection assays (barcoded small RNA sequencing followed by multi-color miRNA in situ hybridization and nested multiplexed PCR with barcoded pyrosequencing) for diagnostic purposes. Although these assays are widely applicable, Neil decided to focus his research on a subset of neurodegenerative diseases that are linked to a defective RNA-binding protein named TAR DNA-binding protein of 43 kilodaltons (TDP43).

Neil successfully obtained NINDS K08 funding to work on post-transcriptional regulation of gene expression in major TDP43 diseases (Frontotemporal Lobar Dementia with ubiquitinated inclusions and TDP43-related Amyotrophic Lateral Sclerosis) from September 2010-August 2015. The central hypothesis of this proposal is that RNA dysregulation is a key pathogenetic mechanism in these diseases. His specific aims are to (1) identify the RNA targets of TDP43 and examine RNA regulatory functions of wild-type and mutant TDP43 (2) assess miRNA regulatory networks in disease tissues and cell lines and (3) estimate sequence variation in TDP43 RNA-binding regions and/or miRNA targeted sites in persons with and without major TDP43 diseases.

Neil's career goal is to establish an experimental pathology laboratory that is dedicated to identifying the causes, delineating the pathomechanisms, and developing therapies for all forms of Amyotrophic Lateral Sclerosis. To achieve this goal, Neil is generously supported by the K08 award mechanism to train in RNA molecular biology, computational biology, and neurodegenerative disease pathology. He continues to be mentored by Prof. Tuschl and is receiving expert instruction in the pathology of neurodegenerative diseases from Prof. John Trojanowski, Center for Neurodegenerative Disease Research, University of Pennsylvania. Neil also participates in the Transition to Scientific Independence Program at Rockefeller University and has a part-time position as an Instructor in Clinical Pathology at Weill Cornell Medical College.

Publications:

1: Briese T, Renwick N, Venter M, Jarman RG, Ghosh D, Köndgen S, Shrestha SK, Hoegh AM, Casas I, Adjogoua EV, Akoua-Koffi C, Myint KS, Williams DT, Chidlow G, van den Berg R, Calvo C, Koch O, Palacios G, Kapoor V, Villari J, Dominguez SR, Holmes KV, Harnett G, Smith D, Mackenzie JS, Ellerbrok H, Schweiger B, Schønning K, Chadha MS, Leendertz FH, Mishra AC, Gibbons RV, Holmes EC, Lipkin WI. Global distribution of novel rhinovirus genotype. Emerg Infect Dis. 2008 Jun;14(6):944-7. PubMed PMID: 18507910.

2: Vladimirtsev VA, Nikitina RS, Renwick N, Ivanova AA, Danilova AP, Platonov FA, Krivoshapkin VG, McLean CA, Masters CL, Gajdusek DC, Goldfarb LG. Family clustering of Viliuisk encephalomyelitis in traditional and new geographic regions. Emerg Infect Dis. 2007 Sep;13(9):1321-6. PubMed PMID: 18252102.

3: Renwick N, Schweiger B, Kapoor V, Liu Z, Villari J, Bullmann R, Miething R, Briese T, Lipkin WI. A recently identified rhinovirus genotype is associated with severe respiratory-tract infection in children in Germany. J Infect Dis. 2007 Dec 15;196(12):1754-60. PubMed PMID: 18190255.

4: Quan PL, Palacios G, Jabado OJ, Conlan S, Hirschberg DL, Pozo F, Jack PJ, Cisterna D, Renwick N, Hui J, Drysdale A, Amos-Ritchie R, Baumeister E, Savy V, Lager KM, Richt JA, Boyle DB, Garcia-Sastre A, Casas I, Perez-Brena, Briese T, Lipkin WI. Detection of respiratory viruses and subtype identification of influenza A viruses by GreeneChipResp oligonucleotide microarray. J Clin Microbiol. 2007 Aug;45(8):2359-64. Epub 2007 Jun 6. PubMed PMID: 17553978.

5: Palacios G, Quan PL, Jabado OJ, Conlan S, Hirschberg DL, Liu Y, Zhai J, Renwick N, Hui J, Hegyi H, Grolla A, Strong JE, Towner JS, Geisbert TW, Jahrling PB, Buchen-Osmond C, Ellerbrok H, Sanchez-Seco MP, Lussier Y, Formenty P, Nichol MS, Feldmann H, Briese T, Lipkin WI. Panmicrobial oligonucleotide array for diagnosis of infectious diseases. Emerg Infect Dis. 2007 Jan;13(1):73-81. PubMed PMID: 17370518.

6: Jabado OJ, Palacios G, Kapoor V, Hui J, Renwick N, Zhai J, Briese T, Lipkin WI. Greene SCPrimer: a rapid comprehensive tool for designing degenerate primers from multiple sequence alignments. Nucleic Acids Res. 2006;34(22):6605-11. Epub 2006 Nov 28. PubMed PMID: 17135211.

7: Lamson D, Renwick N, Kapoor V, Liu Z, Palacios G, Ju J, Dean A, St George K, Briese T, Lipkin WI. MassTag polymerase-chain-reaction detection of respiratory pathogens, including a new rhinovirus genotype, that caused influenza-like illness in New York State during 2004-2005. J Infect Dis. 2006 Nov 15;194(10):1398-402. Epub 2006 Oct 6. PubMed PMID: 17054069.

8: Palacios G, Briese T, Kapoor V, Jabado O, Liu Z, Venter M, Zhai J, Renwick N, Grolla A, Geisbert TW, Drosten C, Towner J, Ju J, Paweska J, Nichol ST, Swanepoel R, Feldmann H, Jahrling PB, Lipkin WI. MassTag polymerase chain reaction for differential diagnosis of viral hemorrhagic fever. Emerg Infect Dis. 2006 Apr;12(4):692-5. PubMed PMID: 16704825.

9: Palacios G, Jabado O, Cisterna D, de Ory F, Renwick N, Echevarria JE, Castellanos A, Mosquera M, Freire MC, Campos RH, Lipkin WI. Molecular identification of mumps virus genotypes from clinical samples: standardized method of analysis. J Clin Microbiol. 2005 Apr;43(4):1869-78. PubMed PMID: 15815011.

10: Palacios G, Jabado O, Renwick N, Briese T, Lipkin WI. Severe acute respiratory syndrome coronavirus persistence in Vero cells. Chin Med J (Engl). 2005 Mar 20;118(6):451-9. PubMed PMID: 15788125.

11: Briese T, Palacios G, Kokoris M, Jabado O, Liu Z, Renwick N, Kapoor V, Casas I, Pozo F, Limberger R, Perez-Brena P, Ju J, Lipkin WI. Diagnostic system for rapid and sensitive differential detection of pathogens. Emerg Infect Dis. 2005 Feb;11(2):310-3. PubMed PMID: 15752453.

12: Gill M, Cohen J, Renwick N, Mones JM, Silvers DN, Celebi JT. Genetic similarities between Spitz nevus and Spitzoid melanoma in children. Cancer. 2004 Dec 1;101(11):2636-40. PubMed PMID: 15503312.

13: Gill M, Renwick N, Silvers DN, Celebi JT. Lack of BRAF mutations in Spitz nevi. J Invest Dermatol. 2004 May;122(5):1325-6. PubMed PMID: 15140238.

14: Renwick N, Nasr SH, Chung WK, Garvin J, Markowitz GS, Marboe C, Thaker HM, D'Agati VD. Foamy podocytes. Am J Kidney Dis. 2003 Apr;41(4):891-6. PubMed PMID: 12666077.

15: Renwick N, Weverling GJ, Brouwer J, Bakker M, Schulz TF, Goudsmit J. Vascular endothelial growth factor levels in serum do not increase following HIV type 1 and HHV8 seroconversion and lack correlation with AIDS-related Kaposi's sarcoma. AIDS Res Hum Retroviruses. 2002 Jul 1;18(10):695-8. PubMed PMID: 12167275.

16: Renwick N, Dukers NH, Weverling GJ, Sheldon JA, Schulz TF, Prins M, Coutinho RA, Goudsmit J. Risk factors for human herpesvirus 8 infection in a cohort of drug users in the Netherlands, 1985-1996. J Infect Dis. 2002 Jun 15;185(12):1808-12. Epub 2002 May 31. PubMed PMID: 12085330.

17: Renwick N, Weverling GJ, Halaby T, Portegies P, Bakker M, Schulz TF, Goudsmit J. Kaposi's sarcoma and human herpesvirus 8 infection do not protect HIV-1 infected homosexual men from AIDS dementia complex. AIDS. 2001 Nov 9;15(16):2165-9. PubMed PMID: 11684936.

18: Renwick N, Weverling GJ, Schulz T, Goudsmit J. Timing of human immunodeficiency virus type 1 and human herpesvirus 8 infections and length of the Kaposi's sarcoma-free period in coinfected persons. J Infect Dis. 2001 May 1;183(9):1427. PubMed PMID: 11294681.

19: van Baarle D, Hovenkamp E, Dukers NH, Renwick N, Kersten MJ, Goudsmit J, Coutinho RA, Miedema F, van Oers MH. High prevalence of Epstein-Barr virus type 2 among homosexual men is caused by sexual transmission. J Infect Dis. 2000 Jun;181(6):2045-9. Epub 2000 May 24. PubMed PMID: 10837190.

20: Goudsmit J, Renwick N, Dukers NH, Coutinho RA, Heisterkamp S, Bakker M, Schulz TF, Cornelissen M, Weverling GJ. Human herpesvirus 8 infections in the Amsterdam Cohort Studies (1984-1997): analysis of seroconversions to ORF65 and ORF73. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4838-43. PubMed PMID: 10781089.

21: Dukers NH, Renwick N, Prins M, Geskus RB, Schulz TF, Weverling GJ, Coutinho RA, Goudsmit J. Risk factors for human herpesvirus 8 seropositivity and seroconversion in a cohort of homosexual men. Am J Epidemiol. 2000 Feb 1;151(3):213-24. PubMed PMID: 10670545.

22: Greensill J, Sheldon JA, Renwick NM, Beer BE, Norley S, Goudsmit J, Schulz TF. Two distinct gamma-2 herpesviruses in African green monkeys: a second gamma-2 herpesvirus lineage among old world primates? J Virol. 2000 Feb;74(3):1572-7. PubMed PMID: 10627572.

23: Prins JM, Sol CJ, Renwick N, Goudsmit J, Veenstra J, Reiss P. Favourable effect of chemotherapy on clinical symptoms and human herpesvirus-8 DNA load in a patient with Kaposi's sarcoma presenting with fever and anemia. Eur J Clin Microbiol Infect Dis. 1999 Jul;18(7):499-502. PubMed PMID: 10482028.

24: Renwick N, Halaby T, Weverling GJ, Dukers NH, Simpson GR, Coutinho RA, Lange JM, Schulz TF, Goudsmit J. Seroconversion for human herpesvirus 8 during HIV infection is highly predictive of Kaposi's sarcoma. AIDS. 1998 Dec 24;12(18):2481-8. PubMed PMID: 9875587.

25: Wit FW, Sol CJ, Renwick N, Roos MT, Pals ST, van Leeuwen R, Goudsmit J, Reiss P. Regression of AIDS-related Kaposi's sarcoma associated with clearance of human herpesvirus-8 from peripheral blood mononuclear cells following initiation of antiretroviral therapy. AIDS. 1998 Jan 22;12(2):218-9. PubMed PMID: 9468373.

26: McNaughton JC, Broom JE, Hill DF, Jones WA, Marshall CJ, Renwick NM, Stockwell PA, Petersen GB. A cluster of transposon-like repetitive sequences in intron 7 of the human dystrophin gene. J Mol Biol. 1993 Jul 5;232(1):314-21. PubMed PMID: 8392588.